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Perioral Dermatitis

  • Writer: KMC
    KMC
  • Jul 11, 2024
  • 2 min read

Updated: Jul 31, 2024

Perioral dermatitis, often referred to as periorificial dermatitis, is a chronic inflammatory skin eruption that most commonly occurs around the mouth but can also occur around the eyes, nostrils, and genitals. This rash is not contagious and usually affects lighter-skinned women between the ages of 20 and 45.

Cause
The etiology of perioral dermatitis is not completely understood. This is often associated with exposure to an allergen or irritant. Risk factors include oral and topical steroid use, cosmetic use, and irritants such as toothpaste. Epidermal barrier disruption, hormonal changes, and atopic disease have also been associated with increased risk.

Clinical Features
This rash appears as small skin-colored to red papules and pustules with a dry, erythematous base surrounding the affected orifice. This rash is occasionally mildly pruritic and associated with increased skin sensitivity.

Complications
Complications can include increased risk of secondary bacterial or fungal infections. Severe rebound flare may also occur after abrupt cessation of topical steroids.

Diagnosis
Diagnosis is often made clinically based on history and appearance. Skin scraping or patch testing can be used to rule out fungal infections or allergic dermatitis. If the diagnosis is uncertain, a biopsy can be performed.

Treatment
Perioral dermatitis is often self-limiting but in persistent cases dermatologic treatment may be required. When treating perioral dermatitis, it is important to switch to mild, fragrance-free skin care products and discontinue all topical steroids. Topical steroids provide temporary relief but will ultimately cause worsening over time. Treatments include oral tetracyclines, topical antibiotics, and calcineurin inhibitors. Oral isotretinoin can also be utilized in severe, refractory cases.

Differential Diagnosis
This condition can resemble acne, rosacea, seborrheic dermatitis, contact dermatitis, and impetigo.

Citation: "Periorificial Dermatitis." (n.d.). DermNet NZ. Retrieved from https://dermnetnz.org/topics/periorificial-dermatitis.

"Perioral Dermatitis: Overview." (n.d.). American Academy of Dermatology. Retrieved from https://www.aad.org/public/diseases/a-z/perioral-dermatitis.






24 Comments


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Pat Bell
Pat Bell
Jan 22

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I think this summary does a great job of explaining perioral dermatitis, and the non-contagious, usual skin areas, and the demographic reasons it occurs in women age 20-45. I also appreciated the assessment of the need for a no rush plan of attack when it comes to treatment. This ‘no rush’ strategy, you see, is quite a familiar process when you consider the US Online Class Taker’program, when you realize planning wins over speeding or even making a joke about ‘pay someone to take my online biology Class’.

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Edited
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fnfunkin
Nov 05, 2025

Dealing with perioral dermatitis can feel like an endless battle, especially when switching up skincare routines and discontinuing steroids causes temporary flare-ups. It’s like trying to hit the right notes in fnf —you think you’ve got it, but then the rash comes back, throwing you off. If you’re struggling with it, a visit to a dermatologist is key to finding the right treatment.

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© 2023 Kansas Medical Clinic, PA ​ - If you have a medical emergency, please call 911.  All information provided herein is for educational purposes only. If you have a medical condition, please consult a physician to get a proper diagnosis and treatment plan.

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