Fibromyalgia
Overview
Fibromyalgia is a chronic musculoskeletal syndrome characterized by pain, achiness, tenderness, and stiffness in the muscle tissue, ligaments, and tendons. It most frequently affects the neck, shoulders, chest, legs, and lower back. Pain is generally accompanied by sleep disorders, fatigue, gastrointestinal disorders, and depression. Many of its symptoms are similar to those of chronic fatigue syndrome, myofascial pain syndrome, and temporomandibular joint syndrome (TMJ).
Incidence and Prevalence
It is estimated that 6 to 8 million people in the United States suffer from fibromyalgia. About 80% of patients are women. While fibromyalgia can occur at any age, the highest incidence occurs among women 20 to 40 years of age.
There have been reports of fibromyalgia in children. What may be considered "growing pains" might in fact be fibromyalgia, especially if the child complains of having difficulty sleeping.
Risk Factors
Risk factors for fibromyalgia include the following:
- Age (more common in young adults)
- Gender (more common in women than men)
- Genetic (familial patterns suggest the disorder may be inherited)
- Sleep disorders (whether sleep difficulties are a cause or a result of fibromyalgia is unknown)
Causes
Causes of fibromyalgia are not known. The condition produces vague symptoms that may be associated with diminished blood flow to certain parts of the brain and increased amounts of substance P, which is thought to be a sensory neurotransmitter involved in the communication of pain, touch, and temperature from the body to the brain. Researchers have identified several other possible causes, including the following:
- Autonomic nervous system dysfunction
- Chronic sleep disorders
- Emotional stress or trauma
- Immune or endocrine system dysfunction
- Upper spinal cord injury
- Viral or bacterial infection
Signs and Symptoms
While the symptoms of fibromyalgia can be debilitating, they are not life threatening. Symptoms vary, depending on stress level, physical activity, time of day, and the weather. Pain is the primary symptom, found in virtually 100% of cases-specifically, pain and tenderness in certain areas of the body when pressure is applied to them. These areas include:
- Back of the head
- Elbows
- Hips
- Knees
- Neck
- Upper back
- Upper chest
Pain may be aching, burning, throbbing, or move around the body (migratory). Many patients also experience muscle tightness, soreness, and spasms. The patient may be unable to carry out normal daily activities, even though muscle strength is not affected. The pain is often worse in the morning, improves throughout the day, and worsens at night.
Fibromyalgia is a chronic condition and symptoms may be constant or intermittent for years or even a lifetime. Other common symptoms of fibromyalgia include:
- Sleep disorders (e.g., restless leg syndrome, sleep apnea)
- Gastrointestinal (e.g., abdominal pain, bloating, gas, cramps, alternating diarrhea and constipation)
- Numbness or tingling sensations
- Chronic headaches (may include facial and jaw pain)
- Heightened sensitivity to odors, loud noises, bright lights, various foods, medicines, and changes in weather
- Painful menstrual periods (dysmenorrhea) and painful sexual intercourse (dyspareunia)
- Frequent urination, strong urge to urinate, and painful urination (dysuria)
- Rapid or irregular heart rate, and shortness of breath
- Sensation of swelling (edema) in the hands and feet, even though swelling is not present
Diagnosis
Diagnosis is based on the exclusion of other conditions, especially chronic fatigue syndrome and myofascial pain syndrome; the patient's history of symptoms; and evidence of tender points located at specific areas of the body.
Tender points are 18 specific points located from the neck to the knees. To diagnose fibromyalgia, at least 11 of these points must be painful when touched. Some physicians believe a patient can have fibromyalgia even if the required number of tender points is not met.
In 1990, the American College of Rheumatology defined two diagnostic criteria for fibromyalgia:
- At least 11 of 18 designated tender points are painful when pressure is applied to them.
- The patient has experienced widespread pain for at least 3 months in all four quadrants of the body (i.e., right and left sides of the body and above and below the waist) or axial skeletal pain (cervical, thoracic, lumbar spine, anterior chest).
Differential Diagnosis
Imaging tests and electrophysiological studies of the nerves and muscles may be performed to rule out illnesses with similar symptoms, including rheumatoid arthritis, lupus, chronic fatigue syndrome (CFS), Lyme disease, muscle diseases (e.g., myofascial pain syndrome), hypothyroidism, and bacterial and viral infections.
Research shows that 50-70% of patients with fibromyalgia also fit the criteria for CFS. However, patients with CFS usually do not meet the criteria for diagnosing fibromyalgia that has been established by the American College of Rheumatology. There is additional physical evidence that the two disorders are distinct. Pain is a hallmark of fibromyalgia and fatigue is a hallmark of CFS. Patients with fibromyalgia may have high levels of substance P in their spinal fluid and CFS patients may not. CFS is thought to be viral in origin, and while a virus is suspected in fibromyalgia, there is no evidence to support it. Symptoms such as fever, sore throat, and swollen glands are more common in patients with CFS. Aerobic exercise often improves muscle function and reduces pain in fibromyalgia, but CFS patients often find that exercise is impossible and worsens symptoms.
Treatment
The goal of treatment is to reduce pain, improve sleep, and relieve associated symptoms. Treatment is tailored to the individual. Some patients experience significant relief of symptoms, some find moderate improvement, and others report little or no relief. Only about 5% of fibromyalgia patients become symptom free.Most treatment regimens include medication, lifestyle changes, exercise, physical therapy, and behavior modification.
Medication
Antidepressant agents known as tricyclics relieve sleep disorders, reduce muscle pain, and treat depression. The tricyclic drug most commonly prescribed for fibromyalgia is amitriptyline (Elavil®).
Another class of antidepressants used in fibromyalgia is selective serotonin-reuptake inhibitors (SSRIs). They boost the level of the neurotransmitter serotonin in the brain, which modulates mood, but do not improve physical symptoms. Fluoxetine (Prozac®) is a commonly prescribed SSRI.
Taking two types of antidepressant may be more effective. A low dose of Prozac combined with Elavil is more effective than either medication used alone.
Antidepressants are first taken at the lowest possible dosage and then gradually increased, if necessary. Their overall benefit appears to be limited, as far as relieving pain, fatigue, and sleeplessness. Many patients are unable to tolerate the side effects of these drugs, even at low doses, and stop taking them. Side effects include nausea, loss of appetite, and insomnia.
Small doses of aspirin or acetaminophen may provide some pain relief and relieve muscle stiffness. Nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen), narcotics, and corticosteroids (e.g., prednisone) have not proven to be effective. Due to potenially severe gastrointestinal and cardiovascular side effects, NSAIDs should only be used as instructed.
In June 2007, the FDA approved pregabalin (Lyrica®) to treat fibromyalgia. This drug reduces pain and improves function in some patients. Side effects include dizziness, excessive sleepiness (somnolence), blurred vision, and weight gain.
Trigger point injections involve injecting a local anesthetic, such as lidocaine, and/or a corticosteroid into a tender point and then stretching the involved muscle. Local anesthetic increases blood flow to the muscle and corticosteroids reduce inflammation. The injections can be painful, and it may take 2 to 4 days for improvement.
Lifestyle Changes
Lifestyle changes that can help alleviate symptoms include avoiding caffeine (it can aggravate sleep disorders), sticking to an exercise program, avoiding nonessential activities, performing tasks more efficiently, establishing regular sleep routines, and eating a healthy diet. Learning relaxation techniques (e.g., meditation, biofeedback) may help control symptoms.
Exercise
Routine low-impact aerobics and strength may help reduce pain, tender-point counts, depression, and sleep disturbance. During aerobic exercise, endorphins, hormone-like substances, are released. Endorphins help relieve pain and produce a feeling of well-being. Walking, swimming, and riding a stationary bicycle provide excellent low-impact aerobic exercise.
The patient should choose an exercise program they enjoy and stick with it because exercise must be routine to be beneficial.
Physical Therapy
Depending on symptoms, heat, ice, massage, whirlpool, ultrasound, and electrical stimulation may be used to reduce pain. Physical therapists can also design an exercise program to improve flexibility, fitness, and posture.
Behavior Modification
Behavior modification involves learning coping skills, relaxation exercises, and self-hypnosis. Pain perception involves both physical and psychological components. Counseling or another type of therapy may help patients learn better methods of coping with their illness, enhance self-esteem, and reduce stress.
Behavioral cognitive therapy effectively strengthens a person's belief in their own abilities and enables them to develop tools for dealing with stress. A specific goal of cognitive therapy is to change the idea that patients are helpless against their pain.
Emotional Support and Education
Patients who take an active role in their care can often improve their quality of life. Emotional support is very important when dealing with a chronic condition such as fibromyalgia. Some patients find support among family and friends, and others find support groups or group therapy to be helpful.