Overview
Carpal tunnel syndrome is a common condition caused by compression, or entrapment, of the motor and sensory nerve in the wrist (median nerve), resulting in pain, muscle weakness, impaired reflexes, numbness, and tingling in the hand. Nerve compression is often associated with repetitive activities (e.g., typing, painting, hammering) that cause stress injury, swelling, and inflammation.
The carpal tunnel is a canal in the wrist through which fibrous connective tissue (tendons), nerves, and blood vessels pass. The transverse carpal ligament covers the carpal tunnel.
Incidence and Prevalence
Incidence of carpal tunnel syndrome is highest in women over the age of 30. The condition may be more prevalent in people who use their wrists in repetitive activity (e.g., typists, computer operators, house painters).
Cause and Risk Factors
Carpal tunnel syndrome is caused by compression of the median nerve. The primary risk factor is a history of another musculoskeletal disorder. The condition develops most often in people who regularly use vibrating machinery and tools and those who use their wrists repetitively, such as:
Hobbies such as rowing, knitting, needlepoint, and gardening may also increase the risk for carpal tunnel syndrome. Other risk factors include underlying medical conditions, such as the following:
Signs and Symptoms
The primary symptoms of carpal tunnel syndrome are pain and numbness in the thumb, index, and middle fingers that often worsen at night and may radiate to the upper arm. Symptoms usually occur near the palm of the hand. Other symptoms include muscle weakness in the hand and wrist, tingling, and impaired reflexes.
In advanced cases of carpal tunnel syndrome, shrinkage (atrophy) of the fleshy area at the base of the thumb may occur.
Diagnosis
Diagnosis of carpal tunnel syndrome is based on the history of symptoms, presence of risk factors, physical and neurological examination, and diagnostic tests.
Neurological examination includes testing the muscle that abducts the thumb away from the palm (called the abductor pollicis brevis), as well as the ability to bend the thumb toward the palm (flexion) and ability to move the thumb toward the other fingers (opposition). Tinel's sign (tapping the palm sharply produces tingling) and Phalen's sign (pressing the backs of the hands together for about 1 minute produces pain and numbness) are also evaluated.
Nerve conduction velocity (NCV) and electromyography (EMG) are used to evaluate nerve and muscle function. NCV involves placing electrodes on the skin above the median nerve to monitor the speed at which an impulse travels along the nerve. EMG involves placing small electrodes into the abductor pollicis brevis muscle to detect abnormalities that may indicate that the median nerve supplying the muscle is damaged. These tests, which are often referred to as EMG/NCV studies, may reveal delayed nerve conduction in the median nerve.
Differential diagnosis includes inflammation (radiculopathy) of nerve roots C6 and C7 in the cervical spine and compression of the median nerve outside the carpal tunnel.
Treatment
Treatment for carpal tunnel syndrome involves activity modification and rest, splinting, medication (including injection therapy), and surgery.
Activity Modification
The first line of treatment usually involves resting the wrist and avoiding activity and movement that worsen symptoms. The wrist may be immobilized using a removable splint. For most patients, wearing the splint at night relieves symptoms, and for others, wearing the splint while at work helps.
When the condition is work related, a work-site evaluation may be performed. An occupational therapist, physical therapist, or rehabilitation consultant is often able to suggest modifications to relieve the condition. Wrist and body positioning can often be improved using ergonomics (science used to fit a job to a person's anatomy and physiology). Improving body position, stretching periodically, and changing positions frequently may help alleviate symptoms.
Medications
Nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen [Advil®, Motrin®]) may be used to relieve pain. Due to potentially severe gastrointestinal and cardiovascular side effects, NSAIDs should only be used as instructed.
Cortisone (a corticosteroid) may be injected into the area around the carpal tunnel to reduce inflammation and nerve compression. Lidocaine (a local anesthetic) may be combined with cortisone, or injected alone, to relieve pain. Lidocaine combined with cortisone produces longer-lasting pain relief.
Surgery
Surgery often provides permanent relief of symptoms when other treatment measures fail. Carpal tunnel release involves cutting the transverse carpal ligament to relieve entrapment of the median nerve. It is usually performed on an outpatient basis, using local, regional, or general anesthesia.
Carpal tunnel release can be performed as open or endoscopic surgery. In open surgery, an incision is made through underlying tissue in the palm of the hand to reach the carpal ligament.
In endoscopic surgery, a smaller incision is made in the wrist and an endoscope is used to locate the carpal ligament. Surgical instruments are inserted through the incision or through a small incision in the palm and the ligament is cut.
Recovery usually takes 3 to 12 months. If compression has caused permanent nerve damage, carpal tunnel release surgery may not be effective.
Complications associated with the surgery include the following:
Laceration of a nerve, blood vessel, or tendon is more common in the endoscopic procedure and this approach is not recommended for patients who have small wrists.
Prognosis
Nonsurgical and surgical treatment for carpal tunnel syndrome relieves symptoms in approximately 90% of cases.
Prevention
Maintaining proper posture, body position, and technique when performing repetitive wrist movements may help to prevent carpal tunnel syndrome. It is important to relax, move around, and change positions frequently when performing any one task for an extended period of time. See a health care provider as soon as possible after symptoms develop.